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| ROUND | PICK | MLB TEAM | PLAYER | POS | SCHOOL | B/T | CLASS | GLSCL TEAM | YEAR IN GLSCL |
| 8 | 240 | Padres | Griffin Doersching | 1B | Northern Ky/Oklahoma St | R/R | GRAD | Hamilton Joes | 2018 |
| 9 | 268 | Angels | Joe Stewart | OF | Michigan State/Michigan | R/R | 5TH-SR | Southern Ohio | 2018 |
| 14 | 433 | Astros | Tommy Sacco | INF | Yavapai/TCU | B/R | SR | St. Clair Green Giants | 2018 |
| 17 | 504 | Twins | Alec Sayre | OF | Wright State | R/R | R-SO | Hamilton Joes | 2020 |
| 17 | 513 | Reds | Easton Sikorski | RHP | Western Michigan | R/R | R-JR | Michigan Monarchs | 2019 |
| UDFA | Tigers | Tyler Johnson | 1B | Coastal Carolina | L/L | SR | Richmond Jazz | 2021 | |
| UDFA | Blue Jays | Kevin Miranda | RHP | LSU-Shreveport | R/R | SR | Lima Locos | 2019 | |
| UDFA | Angels | Griffin Lockwood-Powell | C | Central Michigan | R/R | SR | Irish Hills Leprechauns | 2017 | |
| UDFA | Blue Jays | Grayson Thurman | RHP | Lynchburg College | R/R | SR | Sandusky Bay Ice Haulers | 2021 | |
| UDFA | Reds | Cory Wilder | RHP | N.C. State | R/R | Lima Locos | 2014 | ||
| UDFA | Mariners | Connor Charping | C | Western Michigan | R/R | 5TH-SR | Saginaw Sugar Beets | 2018 | |
| UDFA | Angels | Michael Darrell-Hicks | RHP | Western Ky/Jacksonville St. | R/R | GRAD | Southern Ohio | 2018 |
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